The Rationale Behind the New Alzheimer’s Disease Conceptualization: Lessons Learned During the Last Decades

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The Rationale Behind the New Alzheimer’s Disease Conceptualization: Lessons Learned During the Last Decades

In the last decades, progress in neuroimaging techniques and cerebrospinal fluid assays has enabled the characterization of several Alzheimer's disease (AD) biomarkers. This knowledge has shifted the conceptualization of AD from a clinical-pathological construct, where its diagnosis required the presence of dementia with distinct pathologic features, toward a clinical-biological one that recogn...

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ژورنال

عنوان ژورنال: Journal of Alzheimer's Disease

سال: 2018

ISSN: 1387-2877,1875-8908

DOI: 10.3233/jad-170698